Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in several processes, including positive regulation of cilium assembly; protein localization to motile cilium; and protein targeting to membrane. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RAB3IP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB3IP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB3IP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:69,470,012–69,471,069 | 268.5 kb | Distal (>10kb) Multiome | 831 | |
| chr12:69,585,221–69,586,062 | 153.3 kb | Distal (>10kb) Multiome | 1005 | |
| chr12:69,738,320–69,740,119 | 53 bp | At TSS Multiome | 850 | |
| chr12:69,896,564–69,897,047 | 158.0 kb | Distal (>10kb) Multiome | 121 | |
| chr12:69,910,167–69,911,275 | 171.9 kb | Distal (>10kb) Multiome | 166 |
Genomic view of the RAB3IP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.