Enables GDP binding activity; GTPase activity; and myosin V binding activity. Involved in several processes, including positive regulation of dopamine uptake involved in synaptic transmission; regulation of synaptic vesicle cycle; and regulation of vesicle size. Located in perinuclear region of cytoplasm and vesicle. Is active in dopaminergic synapse and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAB3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:51,729,098–51,730,258 | 261.0 kb | Distal (>10kb) Multiome | 828 | |
| chr1:51,877,934–51,879,493 | 111.8 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:51,957,425–51,958,172 | 32.9 kb | Distal (>10kb) Multiome | 194 | |
| chr1:51,960,124–51,960,875 | 30.2 kb | Distal (>10kb) Multiome | 141 | |
| chr1:51,989,938–51,991,038 | 13 bp | At TSS Multiome | 410 | |
| chr1:51,998,194–51,998,410 | 7.5 kb | Proximal (<10kb) | 17 | |
| chr1:52,032,841–52,033,969 | 43.0 kb | Distal (>10kb) Multiome | 829 | |
| chr1:52,054,893–52,057,012 | 65.7 kb | Distal (>10kb) Multiome | 1080 | |
| chr1:52,141,669–52,142,926 | 151.4 kb | Distal (>10kb) Multiome | 839 | |
| chr1:52,240,504–52,241,012 | 250.1 kb | Distal (>10kb) Multiome | 110 |
Genomic view of the RAB3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.