This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for RAB11FIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB11FIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB11FIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:37,675,185–37,675,906 | 224.0 kb | Distal (>10kb) Multiome | 507 | |
| chr8:37,694,827–37,698,811 | 203.9 kb | Distal (>10kb) Multiome | 830 | |
| chr8:37,735,982–37,737,291 | 163.0 kb | Distal (>10kb) Multiome | 958 | |
| chr8:37,762,144–37,763,270 | 136.9 kb | Distal (>10kb) Multiome | 889 | |
| chr8:37,796,327–37,797,580 | 102.6 kb | Distal (>10kb) Multiome | 485 | |
| chr8:37,801,462–37,802,090 | 97.7 kb | Distal (>10kb) Multiome | 164 | |
| chr8:37,821,399–37,822,221 | 77.6 kb | Distal (>10kb) Multiome | 284 | |
| chr8:37,826,056–37,826,968 | 72.8 kb | Distal (>10kb) Multiome | 259 | |
| chr8:37,849,554–37,850,089 | 49.6 kb | Distal (>10kb) Multiome HiCAR | 929 | |
| chr8:37,890,357–37,890,712 | 8.8 kb | Proximal (<10kb) | 120 | |
| chr8:37,897,613–37,898,359 | 1.1 kb | Proximal (<10kb) | 219 | |
| chr8:37,898,759–37,900,024 | 74 bp | At TSS Multiome | 956 | |
| chr8:37,900,259–37,900,803 | 762 bp | At TSS | 313 | |
| chr8:37,915,980–37,916,519 | 16.8 kb | Distal (>10kb) Multiome | 465 | |
| chr8:37,965,216–37,966,371 | 66.2 kb | Distal (>10kb) Multiome | 177 | |
| chr8:38,015,136–38,015,926 | 116.0 kb | Distal (>10kb) Multiome | 59 | |
| chr8:38,029,913–38,031,249 | 131.0 kb | Distal (>10kb) Multiome | 948 | |
| chr8:38,066,984–38,067,582 | 167.7 kb | Distal (>10kb) Multiome | 414 | |
| chr8:38,070,928–38,072,232 | 172.2 kb | Distal (>10kb) Multiome | 282 | |
| chr8:38,104,797–38,106,255 | 206.2 kb | Distal (>10kb) Multiome | 954 | |
| chr8:38,108,727–38,109,662 | 209.6 kb | Distal (>10kb) Multiome | 83 | |
| chr8:38,175,948–38,177,501 | 277.2 kb | Distal (>10kb) Multiome | 870 |
Genomic view of the RAB11FIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.