The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for RAB11B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB11B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB11B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:8,148,316–8,149,986 | 240.9 kb | Distal (>10kb) Multiome | 381 | |
| chr19:8,203,277–8,204,384 | 186.5 kb | Distal (>10kb) Multiome | 150 | |
| chr19:8,208,086–8,210,178 | 181.2 kb | Distal (>10kb) Multiome | 712 | |
| chr19:8,268,737–8,269,370 | 121.4 kb | Distal (>10kb) Multiome | 272 | |
| chr19:8,307,739–8,308,717 | 82.1 kb | Distal (>10kb) Multiome | 973 | |
| chr19:8,314,738–8,315,490 | 75.3 kb | Distal (>10kb) Multiome | 49 | |
| chr19:8,320,824–8,321,811 | 68.9 kb | Distal (>10kb) Multiome | 871 | |
| chr19:8,334,500–8,335,843 | 55.0 kb | Distal (>10kb) Multiome | 384 | |
| chr19:8,342,762–8,343,678 | 47.0 kb | Distal (>10kb) Multiome | 440 | |
| chr19:8,363,586–8,364,765 | 26.3 kb | Distal (>10kb) Multiome | 549 | |
| chr19:8,389,684–8,391,548 | 122 bp | At TSS Multiome | 878 | |
| chr19:8,396,766–8,396,956 | 6.4 kb | Proximal (<10kb) | 269 | |
| chr19:8,412,769–8,413,775 | 22.8 kb | Distal (>10kb) Multiome | 566 | |
| chr19:8,444,605–8,445,806 | 54.5 kb | Distal (>10kb) Multiome | 910 | |
| chr19:8,505,742–8,506,861 | 115.9 kb | Distal (>10kb) Multiome | 739 | |
| chr19:8,511,414–8,512,588 | 121.7 kb | Distal (>10kb) Multiome | 263 | |
| chr19:8,513,025–8,514,530 | 123.6 kb | Distal (>10kb) Multiome | 825 | |
| chr19:8,525,196–8,527,085 | 135.4 kb | Distal (>10kb) Multiome | 783 | |
| chr19:8,580,484–8,581,056 | 190.6 kb | Distal (>10kb) Multiome | 535 | |
| chr19:8,591,781–8,593,224 | 202.1 kb | Distal (>10kb) Multiome | 389 | |
| chr19:8,609,061–8,609,913 | 219.1 kb | Distal (>10kb) Multiome | 432 | |
| chr19:8,610,265–8,610,915 | 220.5 kb | Distal (>10kb) Multiome | 393 | |
| chr19:10,332,816–10,334,107 | 1943.2 kb | Distal (>10kb) Multiome HiCAR | 882 | |
| chr19:10,334,573–10,335,642 | 1944.7 kb | Distal (>10kb) Multiome HiCAR | 584 |
Genomic view of the RAB11B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.