The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PTPRJ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPRJ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPRJ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:47,714,892–47,715,563 | 265.4 kb | Distal (>10kb) Multiome | 607 | |
| chr11:47,766,463–47,768,105 | 213.3 kb | Distal (>10kb) Multiome | 961 | |
| chr11:47,847,845–47,848,997 | 132.3 kb | Distal (>10kb) Multiome | 863 | |
| chr11:47,916,144–47,917,140 | 64.0 kb | Distal (>10kb) Multiome | 336 | |
| chr11:47,943,718–47,944,629 | 36.6 kb | Distal (>10kb) Multiome | 269 | |
| chr11:47,974,482–47,974,761 | 6.0 kb | Proximal (<10kb) | 163 | |
| chr11:47,979,218–47,981,637 | 220 bp | At TSS Multiome | 548 | |
| chr11:47,986,227–47,986,672 | 5.5 kb | Proximal (<10kb) | 118 | |
| chr11:48,127,687–48,128,434 | 147.5 kb | Distal (>10kb) Multiome HiCAR | 97 |
Genomic view of the PTPRJ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.