The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for PTPRD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPRD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPRD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:8,751,511–8,752,515 | 18.1 kb | Distal (>10kb) Multiome | 88 | |
| chr9:8,856,998–8,859,350 | 124.0 kb | Distal (>10kb) Multiome | 438 | |
| chr9:8,864,280–8,864,772 | 6.5 kb | Proximal (<10kb) | 88 | |
| chr9:8,954,889–8,955,624 | 221.5 kb | Distal (>10kb) Multiome | 81 | |
| chr9:9,102,249–9,102,727 | 368.6 kb | Distal (>10kb) Multiome | 66 | |
| chr9:10,612,349–10,613,992 | 1879.1 kb | Distal (>10kb) Multiome | 390 |
Genomic view of the PTPRD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.