The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for PTPN14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPN14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPN14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:214,280,447–214,282,049 | 270.3 kb | Distal (>10kb) Multiome | 869 | |
| chr1:214,289,711–214,290,215 | 261.6 kb | Distal (>10kb) Multiome | 178 | |
| chr1:214,316,395–214,317,010 | 234.8 kb | Distal (>10kb) Multiome | 226 | |
| chr1:214,317,130–214,317,628 | 234.1 kb | Distal (>10kb) Multiome | 145 | |
| chr1:214,378,748–214,380,041 | 172.0 kb | Distal (>10kb) Multiome HiCAR | 127 | |
| chr1:214,446,675–214,447,519 | 104.5 kb | Distal (>10kb) Multiome HiCAR | 415 | |
| chr1:214,545,289–214,545,916 | 5.7 kb | Proximal (<10kb) | 29 | |
| chr1:214,550,016–214,553,159 | 194 bp | At TSS Multiome | 869 | |
| chr1:214,553,439–214,553,655 | 1.8 kb | Proximal (<10kb) | 24 | |
| chr1:214,602,774–214,603,730 | 51.5 kb | Distal (>10kb) Multiome | 887 | |
| chr1:214,683,504–214,684,332 | 132.2 kb | Distal (>10kb) Multiome | 116 |
Genomic view of the PTPN14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.