This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for PTGR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTGR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTGR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:111,482,713–111,484,706 | 116.6 kb | Distal (>10kb) Multiome | 920 | |
| chr9:111,524,879–111,526,013 | 74.6 kb | Distal (>10kb) Multiome | 531 | |
| chr9:111,529,772–111,530,366 | 69.9 kb | Distal (>10kb) Multiome | 136 | |
| chr9:111,597,856–111,598,818 | 1.8 kb | Proximal (<10kb) Multiome | 424 | |
| chr9:111,599,075–111,600,234 | 117 bp | At TSS Multiome | 464 | |
| chr9:111,603,576–111,604,637 | 4.3 kb | Proximal (<10kb) Multiome | 88 | |
| chr9:111,630,618–111,631,920 | 31.4 kb | Distal (>10kb) Multiome | 1034 | |
| chr9:111,660,898–111,662,420 | 61.6 kb | Distal (>10kb) Multiome | 606 | |
| chr9:111,662,977–111,663,798 | 63.6 kb | Distal (>10kb) Multiome | 132 | |
| chr9:111,896,061–111,897,616 | 297.0 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the PTGR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.