Predicted to enable protein prenyltransferase activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PTAR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTAR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTAR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:69,499,475–69,500,865 | 260.0 kb | Distal (>10kb) Multiome | 110 | |
| chr9:69,671,854–69,673,410 | 87.9 kb | Distal (>10kb) Multiome | 654 | |
| chr9:69,759,439–69,760,486 | 28 bp | At TSS Multiome | 751 | |
| chr9:69,763,746–69,764,079 | 3.7 kb | Proximal (<10kb) | 62 | |
| chr9:69,820,343–69,821,096 | 60.7 kb | Distal (>10kb) Multiome | 239 | |
| chr9:69,823,108–69,824,042 | 63.6 kb | Distal (>10kb) Multiome | 59 | |
| chr9:69,986,283–69,987,113 | 226.7 kb | Distal (>10kb) Multiome | 65 | |
| chr9:70,043,398–70,045,147 | 284.8 kb | Distal (>10kb) Multiome | 310 |
Genomic view of the PTAR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.