Enables RNA binding activity. Involved in stress granule assembly. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRRC2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRRC2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRRC2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:171,219,608–171,221,098 | 264.8 kb | Distal (>10kb) Multiome | 330 | |
| chr1:171,313,680–171,314,256 | 171.5 kb | Distal (>10kb) Multiome | 512 | |
| chr1:171,396,571–171,398,669 | 88.4 kb | Distal (>10kb) Multiome | 230 | |
| chr1:171,431,769–171,432,338 | 53.4 kb | Distal (>10kb) Multiome | 65 | |
| chr1:171,480,132–171,480,349 | 5.2 kb | Proximal (<10kb) | 55 | |
| chr1:171,484,908–171,486,487 | 18 bp | At TSS Multiome | 978 | |
| chr1:171,508,885–171,509,949 | 23.8 kb | Distal (>10kb) Multiome | 157 | |
| chr1:171,641,225–171,641,935 | 156.1 kb | Distal (>10kb) Multiome | 208 | |
| chr1:171,644,792–171,645,779 | 159.7 kb | Distal (>10kb) Multiome | 424 | |
| chr1:171,664,751–171,665,757 | 179.8 kb | Distal (>10kb) Multiome | 206 | |
| chr1:171,741,356–171,742,843 | 256.6 kb | Distal (>10kb) Multiome | 906 | |
| chr1:171,780,733–171,782,347 | 295.9 kb | Distal (>10kb) Multiome | 902 |
Genomic view of the PRRC2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.