Enables RNA binding activity. Predicted to be involved in cell differentiation. Predicted to act upstream of or within in utero embryonic development. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRRC2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRRC2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRRC2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:131,096,120–131,097,337 | 277.2 kb | Distal (>10kb) Multiome | 533 | |
| chr9:131,125,092–131,126,077 | 248.1 kb | Distal (>10kb) Multiome | 873 | |
| chr9:131,177,994–131,178,580 | 195.2 kb | Distal (>10kb) Multiome | 304 | |
| chr9:131,276,571–131,278,332 | 95.5 kb | Distal (>10kb) Multiome | 558 | |
| chr9:131,282,624–131,283,561 | 90.6 kb | Distal (>10kb) Multiome | 217 | |
| chr9:131,330,816–131,331,776 | 42.3 kb | Distal (>10kb) Multiome | 463 | |
| chr9:131,349,882–131,350,535 | 23.4 kb | Distal (>10kb) Multiome | 525 | |
| chr9:131,373,092–131,374,082 | 75 bp | At TSS Multiome | 962 | |
| chr9:131,383,321–131,383,497 | 9.7 kb | Proximal (<10kb) | 386 | |
| chr9:131,385,423–131,385,791 | 8.3 kb | Proximal (<10kb) | 27 | |
| chr9:131,393,060–131,394,879 | 20.3 kb | Distal (>10kb) Multiome | 722 | |
| chr9:131,395,445–131,395,779 | 1.4 kb | Proximal (<10kb) | 276 | |
| chr9:131,407,727–131,408,216 | 34.3 kb | Distal (>10kb) Multiome | 172 | |
| chr9:131,502,603–131,504,327 | 129.4 kb | Distal (>10kb) Multiome | 860 | |
| chr9:131,530,588–131,531,834 | 157.7 kb | Distal (>10kb) Multiome | 635 |
Genomic view of the PRRC2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.