Involved in regulation of cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRR11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRR11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRR11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:59,106,074–59,107,561 | 48.8 kb | Distal (>10kb) Multiome | 1056 | |
| chr17:59,154,270–59,156,000 | 300 bp | At TSS Multiome | 1040 | |
| chr17:59,220,164–59,221,248 | 64.8 kb | Distal (>10kb) Multiome | 819 | |
| chr17:59,289,802–59,290,844 | 134.8 kb | Distal (>10kb) Multiome | 553 | |
| chr17:59,297,022–59,297,671 | 141.5 kb | Distal (>10kb) Multiome | 298 | |
| chr17:59,329,140–59,330,952 | 174.0 kb | Distal (>10kb) Multiome | 623 | |
| chr17:59,331,110–59,332,553 | 175.9 kb | Distal (>10kb) Multiome | 723 | |
| chr17:59,365,177–59,365,986 | 209.9 kb | Distal (>10kb) Multiome | 397 | |
| chr17:59,366,194–59,368,736 | 211.2 kb | Distal (>10kb) Multiome | 784 | |
| chr17:59,370,634–59,371,353 | 215.2 kb | Distal (>10kb) Multiome | 95 | |
| chr17:59,418,775–59,419,543 | 263.4 kb | Distal (>10kb) Multiome | 216 | |
| chr17:59,423,282–59,424,320 | 268.2 kb | Distal (>10kb) Multiome | 316 |
Genomic view of the PRR11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.