This gene encodes a conserved protein containing proline and serine rich regions. These regions may be important in protein-protein interactions. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for PROSER1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PROSER1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PROSER1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:39,037,483–39,038,865 | 3 bp | At TSS Multiome | 925 | |
| chr13:39,047,658–39,047,890 | 9.6 kb | Proximal (<10kb) | 49 | |
| chr13:39,126,837–39,127,606 | 89.2 kb | Distal (>10kb) Multiome | 94 | |
| chr13:39,201,023–39,201,763 | 163.4 kb | Distal (>10kb) Multiome | 125 | |
| chr13:39,385,335–39,386,176 | 347.6 kb | Distal (>10kb) Multiome HiCAR | 268 | |
| chr13:39,602,393–39,603,938 | 564.9 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr13:40,789,168–40,790,225 | 1751.5 kb | Distal (>10kb) Multiome HiCAR | 837 |
Genomic view of the PROSER1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.