Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for PPP6R3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP6R3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP6R3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:68,212,619–68,214,642 | 247.8 kb | Distal (>10kb) Multiome | 967 | |
| chr11:68,271,213–68,272,543 | 188.7 kb | Distal (>10kb) Multiome | 943 | |
| chr11:68,312,404–68,312,863 | 148.1 kb | Distal (>10kb) Multiome | 279 | |
| chr11:68,459,835–68,461,497 | 285 bp | At TSS Multiome | 1017 | |
| chr11:68,683,947–68,685,063 | 223.9 kb | Distal (>10kb) Multiome | 317 | |
| chr11:68,749,819–68,752,106 | 290.8 kb | Distal (>10kb) Multiome | 601 |
Genomic view of the PPP6R3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.