The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for PPP1CC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1CC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1CC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:110,449,732–110,450,544 | 292.6 kb | Distal (>10kb) Multiome | 883 | |
| chr12:110,468,018–110,469,597 | 273.6 kb | Distal (>10kb) Multiome | 1093 | |
| chr12:110,501,642–110,502,585 | 240.7 kb | Distal (>10kb) Multiome | 1115 | |
| chr12:110,582,284–110,583,969 | 159.5 kb | Distal (>10kb) Multiome | 740 | |
| chr12:110,613,705–110,614,482 | 128.8 kb | Distal (>10kb) Multiome | 791 | |
| chr12:110,688,496–110,690,180 | 53.6 kb | Distal (>10kb) Multiome | 414 | |
| chr12:110,742,238–110,743,370 | 98 bp | At TSS Multiome | 801 | |
| chr12:110,772,664–110,773,461 | 30.1 kb | Distal (>10kb) Multiome HiCAR | 88 | |
| chr12:110,846,588–110,847,239 | 104.0 kb | Distal (>10kb) Multiome HiCAR | 371 | |
| chr12:110,860,936–110,861,527 | 118.3 kb | Distal (>10kb) Multiome | 127 | |
| chr12:110,936,931–110,937,646 | 194.4 kb | Distal (>10kb) Multiome | 373 | |
| chr12:111,033,748–111,035,142 | 291.9 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the PPP1CC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.