Enables identical protein binding activity and phosphoprotein phosphatase activity. Predicted to be involved in signal transduction. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PPM1H. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPM1H upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPM1H, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:62,646,389–62,647,205 | 288.4 kb | Distal (>10kb) Multiome | 78 | |
| chr12:62,653,374–62,655,092 | 281.1 kb | Distal (>10kb) Multiome | 290 | |
| chr12:62,659,395–62,659,972 | 275.5 kb | Distal (>10kb) Multiome | 177 | |
| chr12:62,673,057–62,673,824 | 261.6 kb | Distal (>10kb) Multiome | 53 | |
| chr12:62,768,586–62,770,424 | 164.9 kb | Distal (>10kb) Multiome | 179 | |
| chr12:62,792,786–62,794,262 | 141.7 kb | Distal (>10kb) Multiome | 428 | |
| chr12:62,910,025–62,911,247 | 24.4 kb | Distal (>10kb) Multiome | 333 | |
| chr12:62,930,652–62,931,430 | 3.7 kb | Proximal (<10kb) | 82 | |
| chr12:62,933,116–62,935,771 | 29 bp | At TSS Multiome | 1001 | |
| chr12:63,149,823–63,152,592 | 215.6 kb | Distal (>10kb) Multiome | 580 |
Genomic view of the PPM1H locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.