POLR3D

RNA polymerase III subunit D | C53, RPC4, TSBN51, BN51T

This gene complements a temperature-sensitive mutant isolated from the BHK-21 Syrian hamster cell line. It leads to a block in progression through the G1 phase of the cell cycle at nonpermissive temperatures. [provided by RefSeq, Jul 2008]

Member of: DE-4

Biological processes 18 terms

DNA binding (GO:0003677)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)RNA polymerase III complex (GO:0005666)chromatin binding (GO:0003682)chromatin binding (GO:0003682)cytosol (GO:0005829)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of innate immune response (GO:0045089)positive regulation of interferon-beta production (GO:0032728)tRNA transcription by RNA polymerase III (GO:0042797)termination of RNA polymerase III transcription (GO:0006386)transcription by RNA polymerase III (GO:0006383)transcription by RNA polymerase III (GO:0006383)transcription initiation at RNA polymerase III promoter (GO:0006384)

Expression (TPM)

TFs regulating POLR3D 0 TFs

Transcription factors with Perturb-seq knockdown data for POLR3D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLR3D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POLR3D

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLR3D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:22,009,978–22,010,924	234.7 kb	Distal (>10kb) Multiome	885
chr8:22,024,029–22,025,514	219.9 kb	Distal (>10kb) Multiome	508
chr8:22,036,665–22,037,480	208.1 kb	Distal (>10kb) Multiome	457
chr8:22,039,647–22,043,111	205.1 kb	Distal (>10kb) Multiome	407
chr8:22,047,856–22,051,849	195.9 kb	Distal (>10kb) Multiome	566
chr8:22,052,727–22,057,283	191.1 kb	Distal (>10kb) Multiome	541
chr8:22,066,266–22,067,293	178.2 kb	Distal (>10kb) Multiome	612
chr8:22,069,764–22,070,311	175.1 kb	Distal (>10kb) Multiome	85
chr8:22,089,006–22,089,746	155.9 kb	Distal (>10kb) Multiome	562
chr8:22,095,301–22,095,802	149.6 kb	Distal (>10kb) Multiome	199
chr8:22,108,625–22,110,515	135.6 kb	Distal (>10kb) Multiome	907
chr8:22,129,779–22,131,071	114.6 kb	Distal (>10kb) Multiome	440
chr8:22,137,231–22,137,850	107.6 kb	Distal (>10kb) Multiome	531
chr8:22,140,995–22,142,545	103.2 kb	Distal (>10kb) Multiome	753
chr8:22,156,517–22,157,091	88.3 kb	Distal (>10kb) Multiome	215
chr8:22,164,354–22,165,830	80.1 kb	Distal (>10kb) Multiome	672
chr8:22,176,636–22,177,193	68.1 kb	Distal (>10kb) Multiome	91
chr8:22,188,487–22,189,031	56.3 kb	Distal (>10kb) Multiome	334
chr8:22,237,369–22,237,558	7.6 kb	Proximal (<10kb)	335
chr8:22,244,388–22,245,751	10 bp	At TSS Multiome	1013
chr8:22,275,120–22,276,011	30.2 kb	Distal (>10kb) Multiome	195
chr8:22,365,087–22,366,071	120.4 kb	Distal (>10kb) Multiome HiCAR	444
chr8:22,366,837–22,368,383	122.2 kb	Distal (>10kb) Multiome HiCAR	859
chr8:22,440,466–22,441,769	196.0 kb	Distal (>10kb) Multiome	784
chr8:22,561,173–22,562,479	316.7 kb	Distal (>10kb) Multiome HiCAR	678
chr8:22,565,061–22,566,429	320.6 kb	Distal (>10kb) Multiome HiCAR	404
chr8:22,588,723–22,589,902	344.1 kb	Distal (>10kb) Multiome HiCAR	612
chr8:22,594,681–22,595,713	350.1 kb	Distal (>10kb) Multiome HiCAR	402
chr8:22,597,003–22,600,290	352.3 kb	Distal (>10kb) Multiome HiCAR	889

Genome Browser

Genomic view of the POLR3D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.