This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PMPCB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PMPCB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PMPCB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:103,074,047–103,075,916 | 222.4 kb | Distal (>10kb) Multiome | 860 | |
| chr7:103,148,730–103,149,910 | 148.1 kb | Distal (>10kb) Multiome | 1002 | |
| chr7:103,279,769–103,280,793 | 17.0 kb | Distal (>10kb) Multiome | 291 | |
| chr7:103,290,228–103,290,609 | 6.8 kb | Proximal (<10kb) | 13 | |
| chr7:103,297,040–103,297,853 | 50 bp | At TSS Multiome | 880 | |
| chr7:103,344,148–103,345,138 | 47.4 kb | Distal (>10kb) Multiome | 994 | |
| chr7:103,347,517–103,348,162 | 50.3 kb | Distal (>10kb) Multiome | 795 | |
| chr7:103,445,161–103,446,559 | 148.7 kb | Distal (>10kb) Multiome | 424 | |
| chr7:103,597,491–103,598,216 | 300.4 kb | Distal (>10kb) Multiome | 73 | |
| chr7:104,926,844–104,927,636 | 1629.8 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr7:104,944,876–104,945,547 | 1647.8 kb | Distal (>10kb) Multiome HiCAR | 743 | |
| chr7:104,983,612–104,984,567 | 1686.7 kb | Distal (>10kb) Multiome HiCAR | 983 |
Genomic view of the PMPCB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.