Enables CD4 receptor binding activity; enzyme binding activity; and phospholipid scramblase activity. Involved in calcium activated phosphatidylcholine scrambling and calcium activated phosphatidylserine scrambling. Located in nucleus and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLSCR4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLSCR4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLSCR4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:146,160,212–146,161,997 | 89.5 kb | Distal (>10kb) Multiome | 927 | |
| chr3:146,250,453–146,251,614 | 114 bp | At TSS Multiome | 541 | |
| chr3:146,256,973–146,257,353 | 5.8 kb | Proximal (<10kb) | 39 | |
| chr3:146,404,722–146,405,822 | 154.4 kb | Distal (>10kb) Multiome | 141 | |
| chr3:146,468,944–146,470,088 | 218.6 kb | Distal (>10kb) Multiome | 488 | |
| chr3:146,522,213–146,523,383 | 271.9 kb | Distal (>10kb) Multiome | 255 | |
| chr3:146,543,832–146,545,051 | 293.9 kb | Distal (>10kb) Multiome | 819 |
Genomic view of the PLSCR4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.