Enables diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Predicted to be active in membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLPP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLPP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLPP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:120,456,238–120,457,919 | 196 bp | At TSS Multiome | 364 | |
| chr10:120,459,159–120,459,699 | 2.2 kb | Proximal (<10kb) Multiome | 73 | |
| chr10:120,463,307–120,463,774 | 6.1 kb | Proximal (<10kb) | 7 | |
| chr10:120,486,674–120,487,250 | 29.7 kb | Distal (>10kb) Multiome | 19 | |
| chr10:120,513,803–120,514,306 | 56.9 kb | Distal (>10kb) Multiome | 150 | |
| chr10:120,644,648–120,645,329 | 187.8 kb | Distal (>10kb) Multiome | 35 | |
| chr10:120,738,690–120,739,443 | 281.7 kb | Distal (>10kb) Multiome | 85 |
Genomic view of the PLPP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.