Enables N-acyltransferase activity; lipid binding activity; and phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Predicted to be located in several cellular components, including lysosome; nuclear envelope; and peroxisome. Predicted to be active in cytoplasm. Biomarker of seminoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLAAT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAAT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAAT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,489,897–63,491,487 | 123.4 kb | Distal (>10kb) Multiome | 254 | |
| chr11:63,491,633–63,492,303 | 122.5 kb | Distal (>10kb) Multiome | 264 | |
| chr11:63,503,095–63,503,560 | 111.1 kb | Distal (>10kb) Multiome | 72 | |
| chr11:63,610,784–63,611,226 | 3.2 kb | Proximal (<10kb) | 150 | |
| chr11:63,613,506–63,614,656 | 29 bp | At TSS Multiome | 502 | |
| chr11:63,670,776–63,672,118 | 57.2 kb | Distal (>10kb) Multiome | 715 | |
| chr11:63,680,920–63,682,270 | 67.1 kb | Distal (>10kb) Multiome | 869 | |
| chr11:63,761,764–63,765,204 | 149.7 kb | Distal (>10kb) Multiome | 463 | |
| chr11:63,767,471–63,769,982 | 153.2 kb | Distal (>10kb) Multiome | 627 | |
| chr11:63,813,022–63,814,238 | 199.0 kb | Distal (>10kb) Multiome | 704 | |
| chr11:63,838,214–63,839,799 | 224.5 kb | Distal (>10kb) Multiome | 687 | |
| chr11:63,888,171–63,888,861 | 274.1 kb | Distal (>10kb) Multiome | 565 | |
| chr11:63,909,610–63,910,221 | 295.5 kb | Distal (>10kb) Multiome | 113 |
Genomic view of the PLAAT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.