TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for PIP4P2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIP4P2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIP4P2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:89,901,706–89,903,339 | 1138.4 kb | Distal (>10kb) Multiome HiCAR | 906 | |
| chr8:89,983,654–89,985,025 | 1056.5 kb | Distal (>10kb) Multiome HiCAR | 1128 | |
| chr8:90,791,022–90,792,433 | 249.2 kb | Distal (>10kb) Multiome | 362 | |
| chr8:90,984,601–90,986,072 | 55.5 kb | Distal (>10kb) Multiome | 606 | |
| chr8:91,034,348–91,034,867 | 6.0 kb | Proximal (<10kb) | 52 | |
| chr8:91,040,121–91,041,552 | 32 bp | At TSS Multiome | 777 | |
| chr8:91,069,419–91,071,048 | 29.3 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the PIP4P2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.