Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PIMREG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIMREG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIMREG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:5,485,725–5,487,042 | 958.0 kb | Distal (>10kb) Multiome HiCAR | 951 | |
| chr17:5,500,534–5,501,338 | 943.4 kb | Distal (>10kb) Multiome HiCAR | 489 | |
| chr17:5,711,154–5,711,693 | 733.0 kb | Distal (>10kb) Multiome HiCAR | 46 | |
| chr17:6,436,067–6,436,266 | 8.2 kb | Proximal (<10kb) | 127 | |
| chr17:6,443,586–6,444,814 | 193 bp | At TSS Multiome | 802 | |
| chr17:6,495,892–6,496,452 | 51.8 kb | Distal (>10kb) Multiome | 104 | |
| chr17:6,556,250–6,556,832 | 112.1 kb | Distal (>10kb) Multiome | 166 | |
| chr17:6,640,233–6,641,593 | 196.5 kb | Distal (>10kb) Multiome | 878 | |
| chr17:6,650,954–6,652,333 | 207.2 kb | Distal (>10kb) Multiome | 949 | |
| chr17:6,713,294–6,714,088 | 269.2 kb | Distal (>10kb) Multiome | 535 |
Genomic view of the PIMREG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.