The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PIK3C2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3C2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3C2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:16,924,840–16,926,923 | 282.1 kb | Distal (>10kb) Multiome | 568 | |
| chr11:16,956,235–16,957,153 | 251.1 kb | Distal (>10kb) Multiome | 281 | |
| chr11:16,959,532–16,960,122 | 248.1 kb | Distal (>10kb) Multiome | 154 | |
| chr11:16,986,876–16,987,479 | 220.7 kb | Distal (>10kb) Multiome | 258 | |
| chr11:17,013,111–17,015,356 | 194.5 kb | Distal (>10kb) Multiome | 708 | |
| chr11:17,077,236–17,078,393 | 130.2 kb | Distal (>10kb) Multiome | 940 | |
| chr11:17,140,897–17,141,442 | 66.8 kb | Distal (>10kb) Multiome | 103 | |
| chr11:17,207,430–17,209,576 | 162 bp | At TSS Multiome | 1006 | |
| chr11:17,276,170–17,277,311 | 68.7 kb | Distal (>10kb) Multiome | 866 | |
| chr11:17,353,357–17,353,857 | 145.6 kb | Distal (>10kb) Multiome | 768 | |
| chr11:17,388,517–17,389,964 | 181.4 kb | Distal (>10kb) Multiome | 595 | |
| chr11:17,434,869–17,435,423 | 227.3 kb | Distal (>10kb) Multiome | 84 | |
| chr11:17,476,035–17,477,288 | 268.8 kb | Distal (>10kb) Multiome | 247 |
Genomic view of the PIK3C2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.