This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PHLDA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHLDA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHLDA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:75,511,106–75,512,100 | 519.9 kb | Distal (>10kb) Multiome HiCAR | 945 | |
| chr12:75,779,687–75,780,741 | 251.3 kb | Distal (>10kb) Multiome | 288 | |
| chr12:75,892,478–75,893,385 | 138.6 kb | Distal (>10kb) Multiome | 414 | |
| chr12:76,029,985–76,033,119 | 49 bp | At TSS Multiome | 1086 | |
| chr12:76,035,101–76,035,466 | 3.5 kb | Proximal (<10kb) | 54 | |
| chr12:76,036,958–76,037,931 | 5.4 kb | Proximal (<10kb) | 334 | |
| chr12:76,038,033–76,038,382 | 6.4 kb | Proximal (<10kb) | 58 | |
| chr12:76,040,352–76,040,839 | 8.7 kb | Proximal (<10kb) | 27 | |
| chr12:76,083,403–76,085,384 | 53.2 kb | Distal (>10kb) Multiome | 931 | |
| chr12:76,347,962–76,348,990 | 316.8 kb | Distal (>10kb) Multiome HiCAR | 838 |
Genomic view of the PHLDA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.