Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PFAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PFAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PFAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:7,971,685–7,972,375 | 277.4 kb | Distal (>10kb) Multiome | 45 | |
| chr17:7,989,908–7,990,676 | 259.0 kb | Distal (>10kb) Multiome | 652 | |
| chr17:8,015,966–8,016,968 | 233.3 kb | Distal (>10kb) Multiome | 339 | |
| chr17:8,068,609–8,069,844 | 180.5 kb | Distal (>10kb) Multiome | 100 | |
| chr17:8,079,261–8,080,640 | 169.8 kb | Distal (>10kb) Multiome | 613 | |
| chr17:8,109,567–8,110,530 | 139.0 kb | Distal (>10kb) Multiome | 360 | |
| chr17:8,117,780–8,119,396 | 130.3 kb | Distal (>10kb) Multiome | 684 | |
| chr17:8,119,590–8,122,560 | 128.7 kb | Distal (>10kb) Multiome | 968 | |
| chr17:8,123,407–8,124,386 | 125.2 kb | Distal (>10kb) Multiome | 296 | |
| chr17:8,125,308–8,126,995 | 123.5 kb | Distal (>10kb) Multiome | 724 | |
| chr17:8,138,425–8,139,804 | 110.3 kb | Distal (>10kb) Multiome | 981 | |
| chr17:8,151,026–8,151,640 | 98.0 kb | Distal (>10kb) Multiome | 435 | |
| chr17:8,151,914–8,152,786 | 96.8 kb | Distal (>10kb) Multiome | 633 | |
| chr17:8,153,878–8,154,864 | 94.9 kb | Distal (>10kb) Multiome | 644 | |
| chr17:8,155,928–8,157,418 | 92.7 kb | Distal (>10kb) Multiome | 789 | |
| chr17:8,162,377–8,163,907 | 86.2 kb | Distal (>10kb) Multiome | 637 | |
| chr17:8,172,460–8,174,346 | 75.8 kb | Distal (>10kb) Multiome | 1196 | |
| chr17:8,175,900–8,176,943 | 72.9 kb | Distal (>10kb) Multiome | 601 | |
| chr17:8,185,937–8,188,084 | 61.6 kb | Distal (>10kb) Multiome | 1065 | |
| chr17:8,189,376–8,190,688 | 59.0 kb | Distal (>10kb) Multiome | 748 | |
| chr17:8,192,025–8,192,719 | 56.9 kb | Distal (>10kb) Multiome | 452 | |
| chr17:8,210,139–8,210,786 | 38.7 kb | Distal (>10kb) Multiome | 778 | |
| chr17:8,220,662–8,224,088 | 26.3 kb | Distal (>10kb) Multiome | 1171 | |
| chr17:8,226,529–8,227,280 | 22.5 kb | Distal (>10kb) Multiome | 565 | |
| chr17:8,247,519–8,249,589 | 56 bp | At TSS Multiome | 914 | |
| chr17:8,288,100–8,289,230 | 39.5 kb | Distal (>10kb) Multiome | 751 | |
| chr17:8,295,073–8,296,021 | 46.2 kb | Distal (>10kb) Multiome | 739 | |
| chr17:8,310,033–8,310,555 | 61.0 kb | Distal (>10kb) Multiome | 98 | |
| chr17:8,313,329–8,313,824 | 64.3 kb | Distal (>10kb) Multiome | 30 | |
| chr17:8,376,215–8,376,918 | 127.4 kb | Distal (>10kb) Multiome | 888 | |
| chr17:8,382,925–8,384,028 | 134.1 kb | Distal (>10kb) Multiome | 981 | |
| chr17:8,435,307–8,436,885 | 186.6 kb | Distal (>10kb) Multiome | 847 |
Genomic view of the PFAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.