This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for PDGFB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDGFB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDGFB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:39,014,028–39,014,530 | 228.8 kb | Distal (>10kb) Multiome | 367 | |
| chr22:39,020,588–39,021,215 | 222.1 kb | Distal (>10kb) Multiome | 149 | |
| chr22:39,040,158–39,041,304 | 202.1 kb | Distal (>10kb) Multiome | 237 | |
| chr22:39,077,158–39,077,634 | 165.7 kb | Distal (>10kb) Multiome | 66 | |
| chr22:39,087,857–39,088,400 | 155.0 kb | Distal (>10kb) Multiome | 32 | |
| chr22:39,144,772–39,146,359 | 97.3 kb | Distal (>10kb) Multiome | 668 | |
| chr22:39,152,016–39,153,700 | 90.3 kb | Distal (>10kb) Multiome | 607 | |
| chr22:39,170,852–39,171,359 | 71.9 kb | Distal (>10kb) Multiome | 425 | |
| chr22:39,174,292–39,175,258 | 68.1 kb | Distal (>10kb) Multiome | 688 | |
| chr22:39,179,438–39,180,229 | 63.3 kb | Distal (>10kb) Multiome | 84 | |
| chr22:39,229,884–39,230,835 | 12.8 kb | Distal (>10kb) Multiome | 417 | |
| chr22:39,242,211–39,244,345 | 137 bp | At TSS Multiome | 605 | |
| chr22:39,310,537–39,311,897 | 68.1 kb | Distal (>10kb) Multiome | 655 | |
| chr22:39,319,163–39,320,470 | 76.7 kb | Distal (>10kb) Multiome | 968 | |
| chr22:39,349,608–39,350,646 | 106.9 kb | Distal (>10kb) Multiome | 412 | |
| chr22:39,388,249–39,388,891 | 145.4 kb | Distal (>10kb) Multiome | 336 | |
| chr22:39,399,211–39,400,196 | 156.7 kb | Distal (>10kb) Multiome | 896 | |
| chr22:39,501,766–39,502,757 | 259.3 kb | Distal (>10kb) Multiome | 736 | |
| chr22:39,519,211–39,521,337 | 277.2 kb | Distal (>10kb) Multiome | 1150 | |
| chr22:39,528,868–39,529,848 | 286.4 kb | Distal (>10kb) Multiome | 829 | |
| chr22:39,532,183–39,533,171 | 289.8 kb | Distal (>10kb) Multiome | 799 | |
| chr22:39,534,113–39,535,455 | 292.0 kb | Distal (>10kb) Multiome | 621 |
Genomic view of the PDGFB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.