This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for PCSK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCSK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCSK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:117,097,570–117,099,243 | 133.6 kb | Distal (>10kb) Multiome | 739 | |
| chr11:117,099,458–117,100,103 | 132.1 kb | Distal (>10kb) Multiome | 62 | |
| chr11:117,143,916–117,144,864 | 87.7 kb | Distal (>10kb) Multiome | 969 | |
| chr11:117,178,198–117,179,718 | 53.3 kb | Distal (>10kb) Multiome | 726 | |
| chr11:117,197,957–117,198,434 | 34.0 kb | Distal (>10kb) Multiome | 160 | |
| chr11:117,198,962–117,199,797 | 32.8 kb | Distal (>10kb) Multiome | 211 | |
| chr11:117,226,522–117,226,719 | 5.4 kb | Proximal (<10kb) | 133 | |
| chr11:117,231,703–117,233,431 | 467 bp | At TSS Multiome | 703 | |
| chr11:117,315,726–117,316,638 | 84.2 kb | Distal (>10kb) Multiome | 619 | |
| chr11:117,327,486–117,328,627 | 95.8 kb | Distal (>10kb) Multiome | 751 | |
| chr11:117,410,817–117,412,004 | 179.3 kb | Distal (>10kb) Multiome | 247 | |
| chr11:117,429,727–117,430,361 | 198.0 kb | Distal (>10kb) Multiome | 126 | |
| chr11:117,443,412–117,443,876 | 211.7 kb | Distal (>10kb) Multiome | 185 |
Genomic view of the PCSK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.