Enables phospholipid binding activity. Involved in plasma membrane tubulation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PACSIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PACSIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PACSIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:34,196,308–34,196,855 | 269.6 kb | Distal (>10kb) Multiome | 723 | |
| chr6:34,202,245–34,203,164 | 263.3 kb | Distal (>10kb) Multiome | 90 | |
| chr6:34,223,440–34,224,542 | 242.0 kb | Distal (>10kb) Multiome | 795 | |
| chr6:34,234,536–34,237,980 | 229.2 kb | Distal (>10kb) Multiome HiCAR | 1100 | |
| chr6:34,246,464–34,249,721 | 216.9 kb | Distal (>10kb) Multiome | 1030 | |
| chr6:34,391,718–34,393,315 | 73.3 kb | Distal (>10kb) Multiome | 1033 | |
| chr6:34,425,555–34,426,314 | 40.0 kb | Distal (>10kb) Multiome | 859 | |
| chr6:34,457,890–34,458,608 | 7.8 kb | Proximal (<10kb) Multiome | 192 | |
| chr6:34,459,995–34,460,174 | 5.9 kb | Proximal (<10kb) | 164 | |
| chr6:34,462,500–34,462,892 | 3.2 kb | Proximal (<10kb) | 176 | |
| chr6:34,465,686–34,466,203 | 43 bp | At TSS Multiome | 319 | |
| chr6:34,527,078–34,527,644 | 61.3 kb | Distal (>10kb) Multiome | 606 | |
| chr6:34,531,348–34,532,578 | 65.9 kb | Distal (>10kb) Multiome | 150 | |
| chr6:34,696,215–34,697,266 | 230.8 kb | Distal (>10kb) Multiome | 892 | |
| chr6:34,756,834–34,757,760 | 291.3 kb | Distal (>10kb) Multiome | 983 |
Genomic view of the PACSIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.