The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for NUP188. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP188 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP188, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,656,436–128,657,126 | 290.9 kb | Distal (>10kb) Multiome | 1009 | |
| chr9:128,683,393–128,684,010 | 264.1 kb | Distal (>10kb) Multiome | 296 | |
| chr9:128,684,170–128,684,813 | 263.0 kb | Distal (>10kb) Multiome | 574 | |
| chr9:128,688,449–128,689,713 | 258.6 kb | Distal (>10kb) Multiome | 805 | |
| chr9:128,702,246–128,702,946 | 245.1 kb | Distal (>10kb) Multiome | 720 | |
| chr9:128,723,691–128,725,229 | 223.5 kb | Distal (>10kb) Multiome | 821 | |
| chr9:128,771,658–128,772,301 | 175.7 kb | Distal (>10kb) Multiome | 940 | |
| chr9:128,786,928–128,787,516 | 160.5 kb | Distal (>10kb) Multiome | 1040 | |
| chr9:128,818,208–128,819,406 | 129.3 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,829,505–128,830,189 | 117.9 kb | Distal (>10kb) Multiome | 782 | |
| chr9:128,881,863–128,882,454 | 65.6 kb | Distal (>10kb) Multiome | 777 | |
| chr9:128,921,941–128,922,727 | 25.4 kb | Distal (>10kb) Multiome | 378 | |
| chr9:128,947,329–128,947,815 | 63 bp | At TSS Multiome | 865 | |
| chr9:129,027,821–129,028,677 | 80.7 kb | Distal (>10kb) Multiome | 639 | |
| chr9:129,036,276–129,036,937 | 88.8 kb | Distal (>10kb) Multiome | 736 | |
| chr9:129,080,488–129,081,502 | 133.3 kb | Distal (>10kb) Multiome | 755 | |
| chr9:129,110,314–129,111,708 | 163.4 kb | Distal (>10kb) Multiome | 881 | |
| chr9:129,177,207–129,178,809 | 230.6 kb | Distal (>10kb) Multiome | 824 | |
| chr9:129,208,459–129,208,914 | 261.0 kb | Distal (>10kb) Multiome | 108 |
Genomic view of the NUP188 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.