NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
Transcription factors with Perturb-seq knockdown data for NUDT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUDT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUDT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:34,143,812–34,144,483 | 248.5 kb | Distal (>10kb) Multiome | 304 | |
| chr6:34,144,948–34,146,170 | 247.0 kb | Distal (>10kb) Multiome | 310 | |
| chr6:34,196,308–34,196,855 | 196.2 kb | Distal (>10kb) Multiome | 723 | |
| chr6:34,202,245–34,203,164 | 189.9 kb | Distal (>10kb) Multiome | 90 | |
| chr6:34,223,440–34,224,542 | 168.6 kb | Distal (>10kb) Multiome | 795 | |
| chr6:34,234,536–34,237,980 | 155.8 kb | Distal (>10kb) Multiome | 1100 | |
| chr6:34,246,464–34,249,721 | 143.5 kb | Distal (>10kb) Multiome | 1030 | |
| chr6:34,391,718–34,393,315 | 69 bp | At TSS Multiome | 1033 | |
| chr6:34,425,555–34,426,314 | 33.4 kb | Distal (>10kb) Multiome | 859 | |
| chr6:34,457,890–34,458,608 | 65.6 kb | Distal (>10kb) Multiome | 192 | |
| chr6:34,465,686–34,466,203 | 73.3 kb | Distal (>10kb) Multiome | 319 | |
| chr6:34,527,078–34,527,644 | 134.6 kb | Distal (>10kb) Multiome | 606 | |
| chr6:34,531,348–34,532,578 | 139.3 kb | Distal (>10kb) Multiome | 150 |
Genomic view of the NUDT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.