The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for NSMCE3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NSMCE3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NSMCE3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:29,103,497–29,104,203 | 165.9 kb | Distal (>10kb) Multiome | 244 | |
| chr15:29,129,572–29,130,462 | 139.7 kb | Distal (>10kb) Multiome HiCAR | 57 | |
| chr15:29,139,629–29,141,091 | 129.7 kb | Distal (>10kb) Multiome HiCAR | 391 | |
| chr15:29,162,166–29,163,015 | 107.2 kb | Distal (>10kb) Multiome | 45 | |
| chr15:29,215,743–29,217,368 | 52.6 kb | Distal (>10kb) Multiome | 139 | |
| chr15:29,269,106–29,269,978 | 53 bp | At TSS Multiome | 644 | |
| chr15:29,345,363–29,346,382 | 76.0 kb | Distal (>10kb) Multiome | 124 |
Genomic view of the NSMCE3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.