Involved in several processes, including RNA splicing; mRNA stabilization; and positive regulation of RNA export from nucleus. Located in nuclear speck and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NRDE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NRDE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NRDE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:90,060,116–90,062,635 | 271.3 kb | Distal (>10kb) Multiome | 531 | |
| chr14:90,204,480–90,205,107 | 127.2 kb | Distal (>10kb) Multiome | 34 | |
| chr14:90,235,195–90,235,657 | 96.5 kb | Distal (>10kb) Multiome | 401 | |
| chr14:90,256,406–90,256,862 | 75.3 kb | Distal (>10kb) Multiome | 718 | |
| chr14:90,331,584–90,332,424 | 62 bp | At TSS Multiome | 791 | |
| chr14:90,345,568–90,346,463 | 14.2 kb | Distal (>10kb) Multiome | 289 | |
| chr14:90,382,634–90,384,382 | 51.4 kb | Distal (>10kb) Multiome | 1027 | |
| chr14:90,396,430–90,398,792 | 65.0 kb | Distal (>10kb) Multiome | 1151 | |
| chr14:90,399,397–90,399,863 | 67.8 kb | Distal (>10kb) Multiome | 555 | |
| chr14:90,454,113–90,454,877 | 122.5 kb | Distal (>10kb) Multiome | 239 | |
| chr14:90,605,311–90,605,782 | 273.7 kb | Distal (>10kb) Multiome | 80 |
Genomic view of the NRDE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.