The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. This protein is strongly expressed in diverse cell types where it localizes primarily to the nucleus. Based on its similarity to nucleoplasmin and nucleophosmin, this protein likely functions as a molecular chaperone in the cell nucleus. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for NPM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:101,282,747–101,283,297 | 500.4 kb | Distal (>10kb) Multiome HiCAR | 74 | |
| chr10:101,285,534–101,286,046 | 497.5 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr10:101,288,327–101,289,007 | 494.8 kb | Distal (>10kb) Multiome HiCAR | 96 | |
| chr10:101,569,467–101,571,017 | 213.2 kb | Distal (>10kb) Multiome HiCAR | 558 | |
| chr10:101,587,742–101,588,624 | 195.2 kb | Distal (>10kb) Multiome HiCAR | 673 | |
| chr10:101,602,717–101,603,282 | 180.5 kb | Distal (>10kb) Multiome HiCAR | 348 | |
| chr10:101,606,618–101,607,814 | 176.2 kb | Distal (>10kb) Multiome HiCAR | 143 | |
| chr10:101,667,996–101,669,307 | 114.8 kb | Distal (>10kb) Multiome | 135 | |
| chr10:101,694,020–101,695,446 | 89.1 kb | Distal (>10kb) Multiome | 821 | |
| chr10:101,749,494–101,750,047 | 33.7 kb | Distal (>10kb) Multiome | 178 | |
| chr10:101,775,454–101,777,009 | 7.0 kb | Proximal (<10kb) Multiome | 202 | |
| chr10:101,778,233–101,781,743 | 2.3 kb | Proximal (<10kb) Multiome | 720 | |
| chr10:101,782,084–101,782,693 | 752 bp | At TSS | 87 | |
| chr10:101,782,912–101,783,976 | 15 bp | At TSS Multiome | 661 | |
| chr10:101,817,350–101,819,352 | 35.1 kb | Distal (>10kb) Multiome | 1004 | |
| chr10:101,828,926–101,831,154 | 47.4 kb | Distal (>10kb) Multiome | 697 | |
| chr10:101,839,408–101,839,998 | 56.2 kb | Distal (>10kb) Multiome | 196 | |
| chr10:101,840,663–101,841,471 | 57.6 kb | Distal (>10kb) Multiome | 499 | |
| chr10:101,843,178–101,844,328 | 60.3 kb | Distal (>10kb) Multiome | 277 | |
| chr10:101,893,696–101,895,001 | 111.1 kb | Distal (>10kb) Multiome | 142 | |
| chr10:101,960,808–101,961,342 | 177.7 kb | Distal (>10kb) Multiome | 47 | |
| chr10:102,055,474–102,056,435 | 272.7 kb | Distal (>10kb) Multiome | 955 | |
| chr10:102,064,619–102,066,067 | 281.9 kb | Distal (>10kb) Multiome | 778 |
Genomic view of the NPM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.