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DE-1.6

Submodule 38 genes

Lysosomal and vesicular transport functions

Module DE-1.6 contains 38 genes including ANXA2, TXN, LDHA, GSTO1, and CLIC1, with enrichment for lysosomal and vacuolar compartments, vesicle organization, and ion transport processes. Knockdown of SOX17 activates this module.

Key terms: Golgi lumen acidification endosomal lumen acidification lysosomal lumen acidification regulation of lysosomal lumen pH Notable genes: ANXA2 TXN LDHA GSTO1 CLIC1 TUBA1A VAMP8 VDAC2 Top TFs: SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (38)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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