NOP58
NOP58 ribonucleoprotein | HSPC120, NOP5

The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]

Member of: DE-6 DE-6.18 Developmental clusters: GC4
Biological processes 35 terms
ATPase binding (GO:0051117)Cajal body (GO:0015030)RNA binding (GO:0003723)RNA binding (GO:0003723)TFIID-class transcription factor complex binding (GO:0001094)box C/D methylation guide snoRNP complex (GO:0031428)box C/D methylation guide snoRNP complex (GO:0031428)box C/D methylation guide snoRNP complex (GO:0031428)box C/D methylation guide snoRNP complex (GO:0031428)fibrillar center (GO:0001650)mRNA modification (GO:0016556)maturation of SSU-rRNA (GO:0030490)membrane (GO:0016020)neuron differentiation (GO:0030182)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)pre-snoRNP complex (GO:0070761)protein binding (GO:0005515)rRNA 2'-O-methylation (GO:0000451)rRNA processing (GO:0006364)ribosomal small subunit biogenesis (GO:0042274)small-subunit processome (GO:0032040)small-subunit processome (GO:0032040)small-subunit processome (GO:0032040)sno(s)RNA-containing ribonucleoprotein complex (GO:0005732)snoRNA binding (GO:0030515)snoRNA binding (GO:0030515)snoRNA binding (GO:0030515)snoRNA localization (GO:0048254)
Expression (TPM)
NOP58 — as a Regulated Gene

TFs regulating NOP58 0 TFs

Transcription factors with Perturb-seq knockdown data for NOP58. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOP58 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NOP58

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOP58, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:201,972,639–201,973,266 292.7 kb Distal (>10kb) Multiome 195
chr2:202,019,731–202,020,536 245.6 kb Distal (>10kb) Multiome 118
chr2:202,023,052–202,024,286 242.1 kb Distal (>10kb) Multiome 272
chr2:202,032,848–202,036,232 232.0 kb Distal (>10kb) Multiome 769
chr2:202,038,976–202,040,047 226.0 kb Distal (>10kb) Multiome 233
chr2:202,148,653–202,149,792 116.4 kb Distal (>10kb) Multiome 213
chr2:202,163,899–202,164,942 101.2 kb Distal (>10kb) Multiome 79
chr2:202,237,794–202,239,082 27.2 kb Distal (>10kb) Multiome 820
chr2:202,249,669–202,250,510 15.6 kb Distal (>10kb) Multiome 213
chr2:202,265,167–202,266,195 41 bp At TSS Multiome 931
chr2:202,266,532–202,266,730 797 bp At TSS 153
chr2:202,374,983–202,377,090 110.4 kb Distal (>10kb) Multiome 979
chr2:202,417,747–202,419,134 153.0 kb Distal (>10kb) Multiome 197
chr2:202,494,924–202,495,550 229.5 kb Distal (>10kb) Multiome 49

Genome Browser

Genomic view of the NOP58 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:201,962,639 – 202,505,550
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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