The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for NOL7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOL7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOL7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:13,328,084–13,329,043 | 286.8 kb | Distal (>10kb) Multiome HiCAR | 848 | |
| chr6:13,422,574–13,423,098 | 192.5 kb | Distal (>10kb) Multiome | 180 | |
| chr6:13,485,963–13,488,715 | 127.6 kb | Distal (>10kb) Multiome | 753 | |
| chr6:13,532,018–13,532,632 | 83.1 kb | Distal (>10kb) Multiome | 66 | |
| chr6:13,573,806–13,575,472 | 40.9 kb | Distal (>10kb) Multiome | 1136 | |
| chr6:13,614,519–13,616,157 | 47 bp | At TSS Multiome | 1137 | |
| chr6:13,624,706–13,625,116 | 9.4 kb | Proximal (<10kb) | 134 | |
| chr6:13,710,505–13,712,451 | 96.7 kb | Distal (>10kb) Multiome | 996 | |
| chr6:13,813,584–13,814,884 | 199.1 kb | Distal (>10kb) Multiome | 1028 | |
| chr6:13,859,849–13,861,074 | 245.1 kb | Distal (>10kb) Multiome | 81 | |
| chr6:13,873,408–13,874,382 | 258.6 kb | Distal (>10kb) Multiome | 915 |
Genomic view of the NOL7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.