The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for NOA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:56,787,104–56,787,870 | 190.2 kb | Distal (>10kb) Multiome | 101 | |
| chr4:56,821,230–56,822,148 | 155.9 kb | Distal (>10kb) Multiome | 302 | |
| chr4:56,844,583–56,845,457 | 132.6 kb | Distal (>10kb) Multiome | 178 | |
| chr4:56,906,574–56,909,582 | 69.7 kb | Distal (>10kb) Multiome | 887 | |
| chr4:56,976,336–56,979,242 | 28 bp | At TSS Multiome | 954 | |
| chr4:56,979,552–56,979,914 | 1.9 kb | Proximal (<10kb) | 75 | |
| chr4:57,037,888–57,038,581 | 60.7 kb | Distal (>10kb) Multiome | 261 | |
| chr4:57,109,714–57,111,367 | 132.8 kb | Distal (>10kb) Multiome | 438 | |
| chr4:57,163,440–57,164,715 | 186.3 kb | Distal (>10kb) Multiome | 642 | |
| chr4:57,190,721–57,192,448 | 214.2 kb | Distal (>10kb) Multiome | 348 |
Genomic view of the NOA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.