Enables 3'-5' exonuclease activity. Involved in spermatid development. Predicted to be located in 9+2 motile cilium. Predicted to be part of radial spoke. Predicted to be active in cilium. Implicated in primary ciliary dyskinesia. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NME5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NME5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NME5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:138,032,174–138,033,856 | 106.3 kb | Distal (>10kb) Multiome | 889 | |
| chr5:138,036,018–138,036,514 | 103.2 kb | Distal (>10kb) Multiome | 359 | |
| chr5:138,133,089–138,133,415 | 6.0 kb | Proximal (<10kb) | 34 | |
| chr5:138,133,527–138,133,707 | 5.7 kb | Proximal (<10kb) | 129 | |
| chr5:138,139,048–138,139,502 | at TSS | At TSS | 178 | |
| chr5:138,178,349–138,179,428 | 39.5 kb | Distal (>10kb) Multiome | 789 | |
| chr5:138,212,899–138,214,126 | 74.1 kb | Distal (>10kb) Multiome | 747 | |
| chr5:138,241,684–138,242,313 | 102.6 kb | Distal (>10kb) Multiome | 397 | |
| chr5:138,247,699–138,248,212 | 108.5 kb | Distal (>10kb) Multiome | 13 | |
| chr5:138,331,426–138,332,354 | 192.5 kb | Distal (>10kb) Multiome | 686 | |
| chr5:138,337,358–138,339,397 | 198.7 kb | Distal (>10kb) Multiome | 1134 | |
| chr5:138,352,125–138,353,730 | 213.2 kb | Distal (>10kb) Multiome | 868 | |
| chr5:138,438,317–138,439,353 | 299.5 kb | Distal (>10kb) Multiome | 421 |
Genomic view of the NME5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.