This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Transcription factors with Perturb-seq knockdown data for NLRP12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NLRP12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NLRP12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:53,537,348–53,538,212 | 286.6 kb | Distal (>10kb) Multiome | 623 | |
| chr19:53,594,477–53,595,909 | 229.1 kb | Distal (>10kb) Multiome | 262 | |
| chr19:53,612,802–53,613,443 | 211.5 kb | Distal (>10kb) Multiome | 182 | |
| chr19:53,772,960–53,773,600 | 51.3 kb | Distal (>10kb) Multiome | 98 | |
| chr19:53,774,097–53,775,097 | 49.8 kb | Distal (>10kb) Multiome | 24 | |
| chr19:53,792,791–53,793,343 | 31.3 kb | Distal (>10kb) Multiome | 470 | |
| chr19:53,832,920–53,833,128 | 8.5 kb | Proximal (<10kb) | 2 | |
| chr19:53,865,880–53,866,753 | 41.9 kb | Distal (>10kb) Multiome | 532 | |
| chr19:53,866,887–53,869,891 | 43.3 kb | Distal (>10kb) Multiome | 993 | |
| chr19:53,878,918–53,880,011 | 55.1 kb | Distal (>10kb) Multiome | 561 | |
| chr19:53,881,744–53,882,458 | 57.8 kb | Distal (>10kb) Multiome | 435 | |
| chr19:53,889,715–53,890,286 | 65.6 kb | Distal (>10kb) Multiome | 322 | |
| chr19:53,898,176–53,899,412 | 74.6 kb | Distal (>10kb) Multiome | 212 | |
| chr19:53,907,868–53,908,722 | 83.9 kb | Distal (>10kb) Multiome | 276 | |
| chr19:53,941,849–53,943,229 | 118.1 kb | Distal (>10kb) Multiome | 240 | |
| chr19:53,957,309–53,957,858 | 133.1 kb | Distal (>10kb) Multiome | 97 | |
| chr19:53,977,539–53,979,011 | 154.1 kb | Distal (>10kb) Multiome | 412 | |
| chr19:53,979,770–53,982,403 | 156.9 kb | Distal (>10kb) Multiome | 530 | |
| chr19:53,982,560–53,983,015 | 158.4 kb | Distal (>10kb) Multiome | 119 | |
| chr19:54,095,628–54,096,220 | 271.5 kb | Distal (>10kb) Multiome | 457 | |
| chr19:54,102,597–54,103,302 | 278.4 kb | Distal (>10kb) Multiome | 703 | |
| chr19:54,114,870–54,116,009 | 291.1 kb | Distal (>10kb) Multiome | 911 |
Genomic view of the NLRP12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.