This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NLGN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NLGN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NLGN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:173,394,873–173,396,977 | 2.1 kb | Proximal (<10kb) Multiome | 673 | |
| chr3:173,397,146–173,398,513 | 148 bp | At TSS Multiome | 426 | |
| chr3:173,583,411–173,583,866 | 687 bp | At TSS | 55 | |
| chr3:173,584,162–173,584,552 | 1 bp | At TSS | 100 | |
| chr3:173,584,643–173,584,759 | 89 bp | At TSS | 40 | |
| chr3:173,584,862–173,585,841 | 187.8 kb | Distal (>10kb) Multiome | 291 |
Genomic view of the NLGN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.