This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NKTR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NKTR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NKTR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:42,349,668–42,350,325 | 250.7 kb | Distal (>10kb) Multiome | 246 | |
| chr3:42,446,025–42,446,484 | 154.4 kb | Distal (>10kb) Multiome | 27 | |
| chr3:42,501,285–42,503,228 | 98.1 kb | Distal (>10kb) Multiome | 508 | |
| chr3:42,539,796–42,540,344 | 60.6 kb | Distal (>10kb) Multiome | 180 | |
| chr3:42,581,475–42,582,842 | 18.6 kb | Distal (>10kb) Multiome | 889 | |
| chr3:42,590,205–42,591,365 | 9.9 kb | Proximal (<10kb) Multiome | 646 | |
| chr3:42,595,713–42,595,988 | 4.7 kb | Proximal (<10kb) | 30 | |
| chr3:42,600,083–42,601,438 | 39 bp | At TSS Multiome | 914 | |
| chr3:42,653,440–42,655,446 | 54.0 kb | Distal (>10kb) Multiome | 631 | |
| chr3:42,772,623–42,773,428 | 172.6 kb | Distal (>10kb) Multiome | 446 | |
| chr3:42,803,822–42,804,944 | 203.9 kb | Distal (>10kb) Multiome | 881 | |
| chr3:42,805,298–42,806,226 | 205.3 kb | Distal (>10kb) Multiome | 381 | |
| chr3:42,880,478–42,881,506 | 280.5 kb | Distal (>10kb) Multiome | 685 | |
| chr3:42,884,409–42,884,926 | 283.9 kb | Distal (>10kb) Multiome | 59 |
Genomic view of the NKTR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.