NDUFA7

NADH:ubiquinone oxidoreductase subunit A7 | B14.5a

This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]

Member of: DE-1 Developmental clusters: GC5

Biological processes 15 terms

ATP synthesis coupled electron transport (GO:0042773)NADH dehydrogenase (ubiquinone) activity (GO:0008137)aerobic respiration (GO:0009060)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrion (GO:0005739)protein binding (GO:0005515)proton motive force-driven mitochondrial ATP synthesis (GO:0042776)proton transmembrane transport (GO:1902600)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)

Expression (TPM)

TFs regulating NDUFA7 0 TFs

Transcription factors with Perturb-seq knockdown data for NDUFA7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFA7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NDUFA7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFA7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:8,028,908–8,029,518	292.1 kb	Distal (>10kb) Multiome	122
chr19:8,050,174–8,051,154	270.7 kb	Distal (>10kb) Multiome	467
chr19:8,148,316–8,149,986	171.9 kb	Distal (>10kb) Multiome	381
chr19:8,203,277–8,204,384	117.5 kb	Distal (>10kb) Multiome	150
chr19:8,208,086–8,210,178	112.2 kb	Distal (>10kb) Multiome	712
chr19:8,268,737–8,269,370	52.4 kb	Distal (>10kb) Multiome	272
chr19:8,307,739–8,308,717	13.1 kb	Distal (>10kb) Multiome	973
chr19:8,314,738–8,315,490	6.3 kb	Proximal (<10kb) Multiome	49
chr19:8,316,915–8,317,275	4.1 kb	Proximal (<10kb)	81
chr19:8,320,824–8,321,811	47 bp	At TSS Multiome	871
chr19:8,334,500–8,335,843	13.9 kb	Distal (>10kb) Multiome	384
chr19:8,342,762–8,343,678	22.0 kb	Distal (>10kb) Multiome	440
chr19:8,363,586–8,364,765	42.7 kb	Distal (>10kb) Multiome	549
chr19:8,389,684–8,391,548	68.9 kb	Distal (>10kb) Multiome	878
chr19:8,412,769–8,413,775	91.8 kb	Distal (>10kb) Multiome	566
chr19:8,444,605–8,445,806	123.5 kb	Distal (>10kb) Multiome	910
chr19:8,505,742–8,506,861	184.9 kb	Distal (>10kb) Multiome	739
chr19:8,511,414–8,512,588	190.7 kb	Distal (>10kb) Multiome	263
chr19:8,513,025–8,514,530	192.6 kb	Distal (>10kb) Multiome	825
chr19:8,525,196–8,527,085	204.4 kb	Distal (>10kb) Multiome	783
chr19:8,580,484–8,581,056	259.5 kb	Distal (>10kb) Multiome	535
chr19:8,591,781–8,593,224	271.1 kb	Distal (>10kb) Multiome	389
chr19:8,609,061–8,609,913	288.1 kb	Distal (>10kb) Multiome	432
chr19:8,610,265–8,610,915	289.5 kb	Distal (>10kb) Multiome	393

Genome Browser

Genomic view of the NDUFA7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.