NDUFA6

NADH:ubiquinone oxidoreductase subunit A6 | B14, CI-B14, LYRM6, NADHB14

This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. [provided by RefSeq, Oct 2016]

Member of: DE-1 DE-1.19 Developmental clusters: GC5 GC5 GC2

Biological processes 17 terms

NADH dehydrogenase (ubiquinone) activity (GO:0008137)NADH dehydrogenase (ubiquinone) activity (GO:0008137)aerobic respiration (GO:0009060)mitochondrial electron transport, NADH to ubiquinone (GO:0006120)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial membrane (GO:0031966)mitochondrial respiratory chain complex I assembly (GO:0032981)mitochondrion (GO:0005739)proton motive force-driven mitochondrial ATP synthesis (GO:0042776)proton transmembrane transport (GO:1902600)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)respiratory chain complex I (GO:0045271)

Expression (TPM)

TFs regulating NDUFA6 0 TFs

Transcription factors with Perturb-seq knockdown data for NDUFA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NDUFA6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:41,800,274–41,801,345	290.2 kb	Distal (>10kb) Multiome	816
chr22:41,832,291–41,834,215	257.9 kb	Distal (>10kb) Multiome	1023
chr22:41,845,927–41,846,489	244.6 kb	Distal (>10kb) Multiome	271
chr22:41,909,821–41,910,788	180.5 kb	Distal (>10kb) Multiome	251
chr22:41,913,915–41,914,497	176.6 kb	Distal (>10kb) Multiome	143
chr22:41,914,624–41,915,454	175.7 kb	Distal (>10kb) Multiome	273
chr22:41,919,501–41,920,436	170.8 kb	Distal (>10kb) Multiome	337
chr22:41,926,076–41,926,820	164.5 kb	Distal (>10kb) Multiome	442
chr22:41,945,821–41,947,304	143.8 kb	Distal (>10kb) Multiome	896
chr22:41,957,553–41,958,332	132.9 kb	Distal (>10kb) Multiome	456
chr22:41,976,503–41,977,084	114.0 kb	Distal (>10kb) Multiome	294
chr22:42,070,303–42,071,253	19.9 kb	Distal (>10kb) Multiome	833
chr22:42,074,171–42,074,703	16.4 kb	Distal (>10kb) Multiome	178
chr22:42,079,194–42,080,293	11.0 kb	Distal (>10kb) Multiome	872
chr22:42,090,032–42,091,609	142 bp	At TSS Multiome	910
chr22:42,269,385–42,271,172	179.9 kb	Distal (>10kb) Multiome	751
chr22:42,343,251–42,344,201	252.8 kb	Distal (>10kb) Multiome	220
chr22:42,344,438–42,344,933	254.0 kb	Distal (>10kb) Multiome	162
chr22:42,365,301–42,366,142	274.8 kb	Distal (>10kb) Multiome	197
chr22:42,368,263–42,369,908	278.6 kb	Distal (>10kb) Multiome	592
chr22:42,444,134–42,444,723	353.7 kb	Distal (>10kb) Multiome HiCAR	574

Genome Browser

Genomic view of the NDUFA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.