NAXE

NAD(P)HX epimerase | AIBP, MGC119143, MGC119144, MGC119145, YJEFN1, APOA1BP

The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.49

Biological processes 21 terms

NAD(P)HX epimerase activity (GO:0052856)NAD(P)HX epimerase activity (GO:0052856)cell body (GO:0044297)cilium (GO:0005929)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)identical protein binding (GO:0042802)membrane raft distribution (GO:0031580)metabolite repair (GO:0110051)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of angiogenesis (GO:0016525)nicotinamide nucleotide metabolic process (GO:0046496)protein binding (GO:0005515)regulation of cholesterol efflux (GO:0010874)sprouting angiogenesis (GO:0002040)

Expression (TPM)

TFs regulating NAXE 0 TFs

Transcription factors with Perturb-seq knockdown data for NAXE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAXE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NAXE

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAXE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:156,291,233–156,291,857	300.2 kb	Distal (>10kb) Multiome	518
chr1:156,337,825–156,339,056	253.3 kb	Distal (>10kb) Multiome	836
chr1:156,356,873–156,357,393	234.7 kb	Distal (>10kb) Multiome	506
chr1:156,368,893–156,369,552	222.6 kb	Distal (>10kb) Multiome	529
chr1:156,420,712–156,422,291	170.0 kb	Distal (>10kb) Multiome	569
chr1:156,429,277–156,430,847	161.9 kb	Distal (>10kb) Multiome	231
chr1:156,432,112–156,432,986	159.1 kb	Distal (>10kb) Multiome	50
chr1:156,439,076–156,440,265	151.8 kb	Distal (>10kb) Multiome	264
chr1:156,456,348–156,457,982	135.1 kb	Distal (>10kb) Multiome	1033
chr1:156,499,927–156,501,599	90.8 kb	Distal (>10kb) Multiome	950
chr1:156,504,626–156,505,685	86.5 kb	Distal (>10kb) Multiome	911
chr1:156,572,298–156,572,749	19.2 kb	Distal (>10kb) Multiome	580
chr1:156,583,883–156,584,356	7.7 kb	Proximal (<10kb) Multiome	183
chr1:156,584,780–156,585,103	6.7 kb	Proximal (<10kb)	132
chr1:156,591,252–156,592,285	14 bp	At TSS Multiome	706
chr1:156,601,188–156,601,796	9.7 kb	Proximal (<10kb) Multiome	759
chr1:156,624,123–156,624,848	32.7 kb	Distal (>10kb) Multiome	472
chr1:156,641,772–156,642,623	50.3 kb	Distal (>10kb) Multiome	211
chr1:156,657,279–156,657,727	65.8 kb	Distal (>10kb) Multiome	357
chr1:156,659,788–156,660,816	68.4 kb	Distal (>10kb) Multiome	901
chr1:156,673,575–156,674,145	82.1 kb	Distal (>10kb) Multiome	269
chr1:156,676,488–156,677,779	85.6 kb	Distal (>10kb) Multiome	449
chr1:156,689,084–156,690,144	97.8 kb	Distal (>10kb) Multiome	508
chr1:156,692,653–156,693,825	101.4 kb	Distal (>10kb) Multiome	493
chr1:156,703,427–156,704,626	112.1 kb	Distal (>10kb) Multiome	182
chr1:156,704,839–156,707,238	114.4 kb	Distal (>10kb) Multiome	728
chr1:156,708,331–156,708,813	116.7 kb	Distal (>10kb) Multiome	108
chr1:156,728,152–156,729,282	136.9 kb	Distal (>10kb) Multiome	815
chr1:156,740,482–156,741,987	149.4 kb	Distal (>10kb) Multiome	1012
chr1:156,746,390–156,748,386	155.5 kb	Distal (>10kb) Multiome	750
chr1:156,751,012–156,752,594	160.1 kb	Distal (>10kb) Multiome	869
chr1:156,766,695–156,768,280	175.6 kb	Distal (>10kb) Multiome	967
chr1:156,813,606–156,814,470	222.3 kb	Distal (>10kb) Multiome	756
chr1:156,845,268–156,845,794	253.8 kb	Distal (>10kb) Multiome	73
chr1:156,848,614–156,849,138	257.1 kb	Distal (>10kb) Multiome	129
chr1:156,860,147–156,861,294	268.8 kb	Distal (>10kb) Multiome	484
chr1:156,862,753–156,863,585	271.5 kb	Distal (>10kb) Multiome	268

Genome Browser

Genomic view of the NAXE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.