Enables identical protein binding activity and telomerase RNA binding activity. Involved in ribosome biogenesis; telomerase RNA stabilization; and telomerase holoenzyme complex assembly. Acts upstream of or within telomerase RNA localization to Cajal body. Located in cytoplasm and nucleoplasm. Part of sno(s)RNA-containing ribonucleoprotein complex. Implicated in melanoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:162,972,511–162,973,239 | 194.0 kb | Distal (>10kb) Multiome | 89 | |
| chr4:163,166,133–163,167,485 | 7 bp | At TSS Multiome | 882 | |
| chr4:163,171,420–163,172,122 | 4.5 kb | Proximal (<10kb) | 18 | |
| chr4:163,172,349–163,173,039 | 5.5 kb | Proximal (<10kb) | 85 | |
| chr4:163,175,900–163,176,479 | 9.0 kb | Proximal (<10kb) | 12 | |
| chr4:163,186,986–163,187,947 | 20.5 kb | Distal (>10kb) Multiome | 227 | |
| chr4:163,331,418–163,333,442 | 165.9 kb | Distal (>10kb) Multiome | 499 | |
| chr4:163,343,270–163,344,825 | 177.2 kb | Distal (>10kb) Multiome | 372 |
Genomic view of the NAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.