The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for MTFMT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTFMT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTFMT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,774,780–64,776,025 | 254.0 kb | Distal (>10kb) Multiome | 323 | |
| chr15:64,776,175–64,776,789 | 253.0 kb | Distal (>10kb) Multiome | 105 | |
| chr15:64,780,613–64,781,099 | 248.8 kb | Distal (>10kb) Multiome | 74 | |
| chr15:64,807,123–64,808,403 | 221.7 kb | Distal (>10kb) Multiome | 248 | |
| chr15:64,808,791–64,809,297 | 220.5 kb | Distal (>10kb) Multiome | 89 | |
| chr15:64,809,806–64,810,371 | 219.5 kb | Distal (>10kb) Multiome | 298 | |
| chr15:64,823,825–64,824,470 | 205.5 kb | Distal (>10kb) Multiome | 206 | |
| chr15:64,825,130–64,826,273 | 203.8 kb | Distal (>10kb) Multiome | 784 | |
| chr15:64,840,757–64,843,201 | 188.0 kb | Distal (>10kb) Multiome | 732 | |
| chr15:64,893,790–64,894,635 | 135.4 kb | Distal (>10kb) Multiome | 506 | |
| chr15:64,905,276–64,905,958 | 124.0 kb | Distal (>10kb) Multiome | 362 | |
| chr15:64,911,481–64,912,188 | 117.8 kb | Distal (>10kb) Multiome | 308 | |
| chr15:64,915,576–64,916,281 | 113.7 kb | Distal (>10kb) Multiome | 115 | |
| chr15:64,989,345–64,990,371 | 39.7 kb | Distal (>10kb) Multiome | 859 | |
| chr15:65,028,915–65,029,974 | 57 bp | At TSS Multiome | 703 | |
| chr15:65,033,061–65,033,441 | 3.4 kb | Proximal (<10kb) | 467 | |
| chr15:65,049,359–65,049,794 | 19.9 kb | Distal (>10kb) Multiome | 267 | |
| chr15:65,067,081–65,068,384 | 38.5 kb | Distal (>10kb) Multiome | 131 | |
| chr15:65,101,638–65,102,425 | 72.3 kb | Distal (>10kb) Multiome HiCAR | 204 | |
| chr15:65,132,889–65,133,960 | 104.1 kb | Distal (>10kb) Multiome | 775 | |
| chr15:65,184,434–65,185,938 | 155.8 kb | Distal (>10kb) Multiome | 985 | |
| chr15:65,286,029–65,287,330 | 257.3 kb | Distal (>10kb) Multiome | 919 | |
| chr15:65,295,595–65,297,682 | 266.7 kb | Distal (>10kb) Multiome | 1039 | |
| chr15:65,299,879–65,301,676 | 271.4 kb | Distal (>10kb) Multiome | 464 | |
| chr15:65,303,709–65,305,825 | 275.2 kb | Distal (>10kb) Multiome | 1230 |
Genomic view of the MTFMT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.