This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for MTCH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTCH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTCH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:47,354,896–47,355,720 | 287.2 kb | Distal (>10kb) Multiome | 670 | |
| chr11:47,399,791–47,400,763 | 242.2 kb | Distal (>10kb) Multiome | 450 | |
| chr11:47,407,671–47,409,059 | 234.1 kb | Distal (>10kb) Multiome | 986 | |
| chr11:47,425,998–47,427,263 | 216.0 kb | Distal (>10kb) Multiome | 879 | |
| chr11:47,508,005–47,509,036 | 134.0 kb | Distal (>10kb) Multiome | 73 | |
| chr11:47,552,255–47,553,700 | 89.3 kb | Distal (>10kb) Multiome | 834 | |
| chr11:47,564,988–47,566,330 | 76.9 kb | Distal (>10kb) Multiome | 842 | |
| chr11:47,578,427–47,579,510 | 63.6 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:47,589,692–47,590,847 | 52.2 kb | Distal (>10kb) Multiome | 161 | |
| chr11:47,594,122–47,594,733 | 48.2 kb | Distal (>10kb) Multiome | 153 | |
| chr11:47,598,993–47,599,885 | 43.2 kb | Distal (>10kb) Multiome | 67 | |
| chr11:47,642,000–47,643,006 | 39 bp | At TSS Multiome | 973 | |
| chr11:47,714,892–47,715,563 | 72.8 kb | Distal (>10kb) Multiome | 607 | |
| chr11:47,766,463–47,768,105 | 124.9 kb | Distal (>10kb) Multiome | 961 | |
| chr11:47,847,845–47,848,997 | 205.9 kb | Distal (>10kb) Multiome | 863 | |
| chr11:47,916,144–47,917,140 | 274.2 kb | Distal (>10kb) Multiome | 336 |
Genomic view of the MTCH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.