This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for MSI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MSI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MSI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:56,960,529–56,961,254 | 295.6 kb | Distal (>10kb) Multiome | 955 | |
| chr17:56,977,708–56,978,393 | 278.5 kb | Distal (>10kb) Multiome | 552 | |
| chr17:57,084,539–57,086,640 | 171.4 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:57,099,741–57,100,357 | 156.5 kb | Distal (>10kb) Multiome | 119 | |
| chr17:57,255,753–57,257,084 | 130 bp | At TSS Multiome | 661 | |
| chr17:57,257,940–57,258,442 | 1.4 kb | Proximal (<10kb) | 207 | |
| chr17:57,536,308–57,536,893 | 280.0 kb | Distal (>10kb) Multiome | 75 | |
| chr17:57,554,041–57,555,116 | 298.1 kb | Distal (>10kb) Multiome HiCAR | 234 | |
| chr17:57,750,076–57,750,566 | 493.8 kb | Distal (>10kb) Multiome HiCAR | 85 | |
| chr17:57,756,756–57,757,413 | 500.6 kb | Distal (>10kb) Multiome HiCAR | 131 | |
| chr17:57,833,107–57,833,593 | 576.7 kb | Distal (>10kb) Multiome HiCAR | 406 |
Genomic view of the MSI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.