Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRPL17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRPL17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRPL17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,389,605–6,390,990 | 293.0 kb | Distal (>10kb) Multiome | 752 | |
| chr11:6,405,086–6,405,670 | 277.9 kb | Distal (>10kb) Multiome | 99 | |
| chr11:6,418,399–6,419,618 | 264.2 kb | Distal (>10kb) Multiome | 494 | |
| chr11:6,468,896–6,469,642 | 214.1 kb | Distal (>10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 209.3 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,480,885–6,482,114 | 201.9 kb | Distal (>10kb) Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 186.0 kb | Distal (>10kb) Multiome | 71 | |
| chr11:6,586,489–6,587,591 | 96.3 kb | Distal (>10kb) Multiome | 231 | |
| chr11:6,603,192–6,604,726 | 79.6 kb | Distal (>10kb) Multiome | 908 | |
| chr11:6,606,600–6,607,433 | 76.2 kb | Distal (>10kb) Multiome | 532 | |
| chr11:6,611,505–6,613,097 | 71.0 kb | Distal (>10kb) Multiome | 996 | |
| chr11:6,618,753–6,619,738 | 63.9 kb | Distal (>10kb) Multiome | 587 | |
| chr11:6,629,672–6,631,067 | 52.8 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 27.6 kb | Distal (>10kb) Multiome | 314 | |
| chr11:6,678,849–6,679,409 | 3.9 kb | Proximal (<10kb) | 20 | |
| chr11:6,682,693–6,683,793 | 112 bp | At TSS Multiome | 950 | |
| chr11:6,925,579–6,927,200 | 243.2 kb | Distal (>10kb) Multiome | 584 |
Genomic view of the MRPL17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.